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Immuno-Oncology Summit 2025

Back to the Biology: Precision Meets Progress in Immunotherapy

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Bi & Multispecific Engineering
  • Nanobody applications to bi and multispecifics
  • Creating functional bispecifics and multispecifics
  • Target selection
  • Engineering bi/multispecifics for solid tumors

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Translating Multispecific Success
  • Combining multispecifics with cellular modalities
  • ML and data in bi/multispecific development
  • Addressing safety and regulatory hurdles
  • Learnings from solid tumor clinical successes

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Antibody-Drug Conjugates
  • Improvements in linker technologies
  • Site-specific conjugation
  • Addressing resistance and toxicity to improve therapeutic indexes
  • Enhancing solid tumor targeting and specificity for better efficacy
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Breakthroughs in Cell Therapy
  • CAR T therapy
  • TILs, TCRs, Tregs for solid tumor indications
  • Combining multiple cell therapies together
  • Lowering attrition rate in the clinic

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Autoimmunity
  • Learnings from IO applied to autoimmunity
  • B cell targeting
  • Understanding the autoimmunity microenvironment
  • Transient approaches

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Innate Immunity
  • Understanding solid tumor biology
  • NK cell engagers and gamma delta developments
  • ML and data science applications
  • Translatable models
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